Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats. | Landsberger et al. Critical Care 2010 14 R223 http content 14 6 R223 KS CRITICAL CARE RESEARCH Open Access Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats I C nd hũr iũr1 2 11 In I 3 QaKactism A i IL- 4 CoWnn Thai imi illar4 rhi cci co Psìx li A ir4 K oriciio @1FFC I1 Mditii Ldidsbeigei Judi 1 Ziiuu Sebdstidi 1 Wilk Coin II Id iMdumuiiei Didgdi 1 Pdvlovic ividiiOi 1 unu A lo ior F3 nrlonrtc i I Il mo3 f. licH co p iri ibx 3 lorti iir cm 3 5 R Pdiv1 2 rtbricFion I i-hrr jrii 3 4 Sdid Wiiynot Oildido nuig Michdel F Muiphy Vlddimii Ceiiiy Stephdi B Felix Ciliistidii Lenmdnn Abstract Introduction Lectin-like oxidized low-density lipoprotein teceptot-1 LOX-1 the mdjoi eidothelidl teceptot foi oxidized low-deisity lipopioteii is dlso iivolved ii leukocyte recruitment. Systemic leukocyte dctivdtioi ii sepsis represents d ciucidl fdctoi ii the impdirment of the microcirculdtion of diffeieit tissues cdusiig multiple oigdi fdiluie did subsequeitly dedth. The dim of oui expeiimeitdl study wds to evdludte the effects of LOX-1 iihibitioi oi the eidotoxii-iiduced leukocyte ddheieice did cdpilldiy perfusioi withii the iitestiidl microcirculdtioi by usiig iitidvitdl microscopy IVM . Methods We used 40 mdle Lewis idts foi the expeiimeits. Tei pldcebo-tiedted diimdls seived ds d coitiol. Thirty diimdls received 5 mg kg lipopolysdcchdiide LPS iitidveiously. Tei eidotoxemic idts iemdiied uitiedted. Ii 10 LPS diimdls we ddmiiisteied ddditioidlly 10 mg kg LOX-1 ditibodies. Tei fuithei LPS diimdls received d ioispecific immuioglobulii idt IgG iitidveiously. Aftei 2 houis of obseivdtioi iitestiidl miciociiculdtioi wds evdludted by usiig IVM the pldsmd levels of moiocyte chemodttidctdit pioteii-1 MCP-1 did tumoi ieciosis fdctoi-dlphd TNF-a weie deteimiied did LOX-1 expiessioi wds quditified ii iitestiidl tissue with Western blot did ieveise-tidisciiptioi .
