Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Usefulness of N-terminal pro-brain natriuretic peptide and C-reactive protein to predict ICU mortality in unselected medical ICU patients: a prospective, observational study. | Wang et al. Critical Care 2011 15 R42 http content 15 1 R42 KS CRITICAL CARE RESEARCH Open Access Usefulness of N-terminal pro-brain natriuretic peptide and C-reactive protein to predict ICU mortality in unselected medical ICU patients a prospective observational study Feilong WangC Wenzhi Pan2t Shuming Pan1 Shuyun Wang1 Qinmin Ge1 Junbo Ge2 Abstract Introduction The performance of N-terminal pro-brain natriuretic peptide NT-proBNP and C-reactive protein CRP to predict clinical outcomes in ICU patients is unimpressive. We aimed to assess the prognostic value of NT-proBNP CRP or the combination of both in unselected medical ICU patients. Methods A total of 576 consecutive patients were screened for eligibility and followed up during the ICU stay. We collected each patient s baseline characteristics including the Acute Physiology and Chronic Health Evaluation II APACHE-II score NT-proBNP and CRP levels. The primary outcome was ICU mortality. Potential predictors were analyzed for possible association with outcomes. We also evaluated the ability of NT-proBNP and CRP additive to APACHE-II score to predict ICU mortality by calculation of C-index net reclassification improvement NRI and integrated discrimination improvement IDI indices. Results Multiple regression revealed that CRP NT-proBNP APACHE-II score and fasting plasma glucose independently predicted ICU mortality all P . The C-index with respect to prediction of ICU mortality of APACHE II score P was greater than that of NT-proBNP P or CRP P all P . As compared with APACHE-II score P combination of CRP P or NT-proBNP P or both P with APACHE-II score did not significantly increase C-index for predicting ICU mortality all P . However addition of NT-proBNP to aPaCHE-II score gave IDI of P and NRI of P addition of CRP to APACHE-II score provided IDI of P .
