Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Endothelial Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. | Koch et al. Critical Care 2011 15 R63 http content 15 1 R63 KS CRITICAL CARE RESEARCH Open Access Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients 11 2 111 Alexander Koch Sebastian Voigt Carsten Kruschinski Edouard Sanson Hanna Duckers Andreas Horn Eray Yagmur3 Henning Zimmermann1 Christian Trautwein1 and Frank Tacke1 Abstract Introduction suPAR is the soluble form of the urokinase plasminogen activator receptor uPAR which is expressed in various immunologically active cells. High suPAR serum concentrations are suggested to reflect the activation of the immune system in circumstances of inflammation and infection and have been associated with increased mortality in different populations of non-intensive care patients. In this study we sequentially analyzed suPAR serum concentrations within the first week of intensive care in a large cohort of well characterized intensive care unit ICU patients in order to investigate potential regulatory mechanisms and evaluate the prognostic significance in critically ill patients. Methods A total of 273 patients 197 with sepsis 76 without sepsis were studied prospectively upon admission to the medical intensive care unit ICU on Day 3 and Day 7 and compared to 43 healthy controls. Clinical data various laboratory parameters as well as investigational inflammatory cytokine profiles were assessed. Patients were followed for approximately one year. Results Upon admission to the ICU suPAR serum concentrations were elevated in critically ill patients as compared with healthy controls. In sepsis patients suPAR levels were higher than in non-sepsis patients with or without systemic inflammatory response syndrome SIRS . During the first week after admission to the ICU serum suPAR concentrations remained stably elevated. suPAR serum concentrations measured upon admission were closely and
