Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Extracorporeal cell therapy of septic shock patients with donor granulocytes: a pilot study. | Altrichter et al. Critical Care 2011 15 R82 http content 15 2 R82 KS CRITICAL CARE RESEARCH Open Access Extracorporeal cell therapy of septic shock patients with donor granulocytes a pilot study I o u . r- ỉ I ri r 4- - r 1 k ỉ V- -in c I I o r2 IX I . rim IX 1 I h r D I r I 2 r I r fZ. I r3 k ỉ rf- xz I V4 I As m I_I r r fs 14 Jens Altrichter Martin Sauer Katharina Kaftan Thomas Birken Doris Gloger Martin Gloger Jorg Henschel Heiko Hickstein1 Ernst Klar5 Sebastian Koball1 Annette Pertschy5 Gabriele Noldge-Schomburg2 DierK A Vagts2 and Steffen R Mitzner1 Abstract Introduction Neutrophil granulocytes are the first defense line in bacterial infections. However granulocytes are also responsible for severe local tissue impairment. In order to use donor granulocytes but at the same time to avoid local side effects we developed an extracorporeal immune support system. This first-in-man study investigated whether an extracorporeal plasma treatment with a granulocyte bioreactor is tolerable in patients with septic shock. A further intention was to find suitable efficacy end-points for subsequent controlled trials. Methods The trial was conducted as a prospective uncontrolled clinical phase I II study with 28-day follow-up at three university hospital intensive care units. Ten consecutive patients five men five women mean age standard deviation SD years with septic shock with mean ICU entrance scores of Acute Physiology and Chronic Health Evaluation APACHE II of and of Simplified Acute Physiology Score SAPS II of were treated twice within 72 hours for a mean of 342 64 minutes treatment with an extracorporeal bioreactor containing X 10E10 granulocytes from healthy donors. On average liters separated plasma were treated by the therapeutic donor cells. Patients were followed up for 28 days. Results Tolerance and technical safety during treatment single organ functions pre post treatment and hospital survival were .
