Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study. | Bloos et al. Critical Care 2011 15 R88 http content 15 2 R88 KS CRITICAL CARE RESEARCH Open Access Multinational observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation a multicenter observational study l-root Rlrvcvc 1 f l rercholl2 DichorH p rtdllioddr3 aim- CM lie Vỉnront4 @1 Ipicurrci-Z5 id Pi drc6 FidiiK Bloos John C Mdisiidll Riciidid P Dellingei Jedn Louis Vincent Guilleimo Gutieiiez cmdRUci Riveis D r A 0 -- I 1 7 on c r r I r I Ì z- lz Í A I I I r 9 IZ I n Dn hirf tiK l Dr 11 lz f r e 1 nobeit A BdlK rieiie-Fidncois Ldteiie DeieK C Angus Konidd Keinndif FidnK M DiunKnoist Abstract Introduction The intent of this study wds to deteimine whethei seium piocdlcitonin PCT levels die dssocidted with prognosis medsuied ds oigdn dysfunctions dnd 28-ddy moitdlity in pdtients with seveie pneumonid. Methods This wds d multicentei obseivdtiondl study of ciiticdlly ill ddult pdtients with pneumonid requiring mechdnicdl ventildtion conducted in 10 dcddemic hospitdls in Cdnddd the United Stdtes dnd Centidl Europe. PCT wds medsuied ddily foi 14 ddys using dn immuno-luminometiic dssdy. Results We included 175 pdtients 57 with community dcquiied pneumonid CAP 61 with ventildtoi dssocidted pneumonid VAP dnd 57 with hospitdl dcquiied pneumonid HAP . Initidl PCT levels weie highei in CAP thdn VAP pdtients medidn inteiquditile range IQR to vs. to ng ml P but not significdntly different to HAP to ng ml . The 28-ddy ICU moitdlity idte foi dll pdtients wds with d medidn ICU length of stdy of 16 ddys idnge 1 to 142 ddys . PCT levels weie highei in non-suivivois thdn in suivivois. Initidl dnd mdximum PCT levels coiieldted with mdximum Sequentidl Oigdn Fdiluie Assessment SOFA scoie i2 95 CI to dnd i2 to respectively. Receivei operating cuive ROC dndlysis on disciimindtion of 28-ddy mortality showed dieds undei the cuive AUC of dnd
