Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: ngLOC: an n-gram-based Bayesian method for estimating the subcellular proteomes of eukaryotes. | Method Open Access ngLOC an n-gram-based Bayesian method for estimating the subcellular proteomes of eukaryotes Brian R King and Chittibabu Gudan Addresses Department of Computer Science State University of New York at Albany Washington Ave Albany New York 12222 USA. tGen NY sis Center for Excellence in Cancer Genomics State University of New York at Albany Discovery Drive Rensselaer New York 121443456 USA. Department of Epidemiology and Biostatistics State University of New York at Albany Discovery Drive Rensselaer New York 12144-3456 USA. Correspondence Chittibabu Guda. Email cguda@ Published I May 2007 Genome Biology 2007 8 R68 doi 186 gb-2007-8-5-r68 The electronic version of this article is the complete one and can be found online at http 2007 8 5 R68 Received 7 November 2006 Revised 19 February 2007 Accepted 1 May 2007 2007 King and Guda licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We present a method called ngLOC an n-gram-based Bayesian classifier that predicts the localization of a protein sequence over ten distinct subcellular organelles. A tenfold cross-validation result shows an accuracy of 89 for sequences localized to a single organelle and 82 for those localized to multiple organelles. An enhanced version of ngLOC was developed to estimate the subcellular proteomes of eight eukaryotic organisms yeast nematode fruitfly mosquito zebrafish chicken mouse and human. Background Subcellular or organellar proteomics has gained tremendous attention of late owing to the role played by organelles in carrying out defined cellular processes. Several efforts have been made to catalog the complete subcellular proteomes of various model organisms for review 1 2 with the aim being
