Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma. | Research Open Access Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53 nuclear factor-KB and other signal transcription factors in head and neck squamous cell carcinoma Bin Yan Xinping Yang Tin-Lap Lee Jay Friedman Jun Tang Carter Van Waes and Zhong Chen Addresses Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders National Institutes of Health Center Drive Bethesda Maryland 20892 USA. Taboratoiy of Clinical Genomics National Institute of Child Health and Human Development National Institutes of Health Convent Drive Bethesda MD 20892 USA. Department of Preventive Medicine University of Tennessee Health Science Center N Pauline St. Memphis TN 38163 USA. Correspondence Zhong Chen. Email chenz@ Published II May 2007 Genome Biology 2007 8 R78 doi I86 gb-2007-8-5-r78 The electronic version of this article is the complete one and can be found online at http 2007 8 5 R78 Received I7 October 2006 Revised 7 February 2007 Accepted I I May 2007 2007 Yan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Differentially expressed gene profiles have previously been observed among pathologically defined cancers by microarray technologies including head and neck squamous cell carcinomas HNSCCs . However the molecular expression signatures and transcriptional regulatory controls that underlie the heterogeneity in HNSCCs are not well defined. Results Genome-wide cDNA microarray profiling of ten HNSCC cell lines revealed novel gene expression signatures that distinguished cancer cell subsets associated with p53 status. Three major clusters of over-expressed genes A to C
