Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: School of Computer Science and Engineering, Hebrew University. | Research Open Access Functional coordination of alternative splicing in the mammalian central nervous system Matthew FagnaniH Yoseph BarashH Joanna Y Ip Christine Misquitta Qun Pan Arneet L Saltzman Ofer Shai Leo Lee Aviad Rozenhek Naveed Mohammad Sandrine Willaime-Morawek Tomas Babak Wen Zhang Timothy R Hughes Derek van der Kooy Brendan J Frey and Benjamin J Blencowe Addresses Banting and Best Department of Medical Research Centre for Cellular and Biomolecular Research University of Toronto 160 College Street Toronto Ontario Canada. M5S 3E1. Department of Molecular and Medical Genetics Centre for Cellular and Biomolecular Research University of Toronto 160 College Street Toronto Ontario Canada. M5S 3E1. Department of Electrical and Computer Engineering University of Toronto 40 St. George s Street Toronto Ontario Canada. School of Computer Science and Engineering Hebrew University Jerusalem 91904 Israel. H These authors contributed equally to this work. Correspondence Brendan J Frey. Email frey@. Benjamin J Blencowe. Email Published 12 June 2007 Genome Biology 2007 8 R108 doi gb-2007-8-6-rl 08 The electronic version of this article is the complete one and can be found online at http 2007 8 6 R108 Received 18 October 2006 Revised 22 January 2007 Accepted l2 June 2007 2007 Fagnani et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Alternative splicing AS functions to expand proteomic complexity and plays numerous important roles in gene regulation. However the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover the sequence code that underlies cell and tissue type specific regulation of
