Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. | Open Access Research Comparative analysis of transposed element insertion within human and mouse genomes reveals Alus unique role in shaping the human transcriptome Noa Sela Britta Mersch Nurit Gal-Mark Galit Lev-Maor Agnes Hotz-Wagenblatf and Gil Ast Addresses Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University Ramat Aviv 69978 Israel. HUSAR Bioinformatics Lab Department of Molecular Biophysics German Cancer Research Center DKFZ Im Neuenheimer Feld D69120 Heidelberg Germany. Correspondence Gil Ast. Email gilast@ Published 27 June 2007 Genome Biology 2007 8 R127 doi gb-2007-8-6-rl 27 The electronic version of this article is the complete one and can be found online at http 2007 8 6 R127 Received 17 January 2007 Revised 7 June 2007 Accepted 27 June 2007 2007 Sela et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transposed elements TEs have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome and the mouse transcriptome. Results We compiled a dataset of all TEs in the human and mouse genomes identifying 3 932 058 and 3 122 416 TEs respectively. We than extracted TEs located within human and mouse genes and surprisingly we found that 60 of TEs in both human and mouse are located in intronic sequences even though introns comprise only 24 of the human genome. All TE families in both human and mouse can exonize. TE families that are shared between human and mouse exhibit the same percentage of TE exonization in the two species but the exonization level of Alu a primatespecific retroelement is significantly greater than .
