Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes. | Open Access Research Modeling Neisseria meningitidis metabolism from genome to metabolic fluxes Gino JE Baart Bert Zomer Alex de Haan Leo A van der Pol E Coen Beuvery Johannes Tramper and Dirk E Martens Addresses Unit Research Development Netherlands Vaccine Institute NVI PO Box 457 3720 AL Bilthoven The Netherlands. TAT Consultancy Kerkstraat 66 4132 BG Vianen The Netherlands. Food and Bioprocess Engineering Group Wageningen University PO Box 8129 6700 EV Wageningen The Netherlands. Correspondence Gino JE Baart. Email Published 6 July 2007 Genome Biology 2007 8 R136 doi gb-2007-8-7-r136 The electronic version of this article is the complete one and can be found online at http 2007 8 7 R136 Received 14 December 2006 Revised 16 March 2007 Accepted 6 July 2007 2007 Baart et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible for death and disability especially in young infants. In general most of the recent work on N. meningitidis focuses on potential antigens and their functions immunogenicity and pathogenicity mechanisms. Very little work has been carried out on Neisseria primary metabolism over the past 25 years. Results Using the genomic database of N. meningitidis serogroup B together with biochemical and physiological information in the literature we constructed a genome-scale flux model for the primary metabolism of N. meningitidis. The validity of a simplified metabolic network derived from the genome-scale metabolic network was checked using flux-balance analysis in chemostat cultures. Several useful
