Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Housekeeping genes tend to show reduced upstream sequence conservation. | Open Access Research Housekeeping genes tend to show reduced upstream sequence conservation Domènec Farré Nicolás Bellora ỷ Loris Mularoni Xavier Messeguer and M Mar Albà Addresses Centre for Genomic Regulation Dr Aiguader 88 Barcelona 08003 Spain. Universitat Pompeu Fabra Dr Aiguader 88 Barcelona 08003 Spain. Fundació Institut Municipal d Investigacio Mèdica Dr Aiguader 88 Barcelona 08003 Spain. Universitat Politècnica de Catalunya Jordi Girona 1-3 Barcelona 08034 Spain. Catalan Institution for Research and Advanced Studies Pg Lluis Companys 23 Barcelona 08010 Spain. Correspondence M Mar Albà. Email malba@ Published 13 July 2007 Received 20 October 2006 Genome Biology 2007 8 R140 doi gb-2007-8-7-r140 eL16. February2 07 gy g Accepted 13 July 2007 The electronic version of this article is the complete one and can be found online at http 2007 8 7 R140 2007 Farré et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Understanding the constraints that operate in mammalian gene promoter sequences is of key importance to understand the evolution of gene regulatory networks. The level of promoter conservation varies greatly across orthologous genes denoting differences in the strength of the evolutionary constraints. Here we test the hypothesis that the number of tissues in which a gene is expressed is related in a significant manner to the extent of promoter sequence conservation. Results We show that mammalian housekeeping genes expressed in all or nearly all tissues show significantly lower promoter sequence conservation especially upstream of position -500 with respect to the transcription start site than genes expressed in a subset of tissues. In addition we evaluate the .
