Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Species-specific shifts in centromere sequence composition are coincident with breakpoint reuse in karyotypically divergent lineages. | Open Access Research Species-specific shifts in centromere sequence composition are coincident with breakpoint reuse in karyotypically divergent lineages Kira V Bulazel Gianni C Ferreri Mark DB Eldridge and Rachel J O Neill Addresses Department of Molecular and Cell Biology Mansfield Rd University of Connecticut Storrs CT 06269 USA. Department of Biological Sciences Macquarie University NSW 2109 Australia. Molecular Biology Australian Museum College St Sydney NSW 2010 Australia. Correspondence Rachel J O Neill. Email Published 20 August 2007 Genome Biology 2007 8 RI70 doi gb-2007-8-8-rl 70 The electronic version of this article is the complete one and can be found online at http 2007 8 8 R170 Received 6 July 2007 Revised I4 August 2007 Accepted 20 August 2007 2007 Bulazel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It has been hypothesized that rapid divergence in centromere sequences accompanies rapid karyotypic change during speciation. However the reuse of breakpoints coincident with centromeres in the evolution of divergent karyotypes poses a potential paradox. In distantly related species where the same centromere breakpoints are used in the independent derivation of karyotypes centromere-specific sequences may undergo convergent evolution rather than rapid sequence divergence. To determine whether centromere sequence composition follows the phylogenetic history of species evolution or patterns of convergent breakpoint reuse through chromosome evolution we examined the phylogenetic trajectory of centromere sequences within a group of karyotypically diverse mammals macropodine marsupials wallabies wallaroos and kangaroos . Results The .
