Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Metabolic peculiarities of Aspergillus niger disclosed by comparative metabolic genomics. | Research Open Access Metabolic peculiarities of Aspergillus niger disclosed by comparative metabolic genomics Jibin Sun Xin Lu Ursula Rinas and An Ping Zeng Addresses Helmholtz Centre for Infection Research Inhoffenstr. 38124 Braunschweig Germany. Hamburg University of Technology Institute of Bioprocess and Biosystems Engineering Denickestr. 21071 Hamburg Germany. Correspondence An Ping Zeng. Email aze@ Published 4 September 2007 Genome Biology 2007 8 RI82 doi gb-2007-8-9-rI 82 The electronic version of this article is the complete one and can be found online at http 2007 8 9 RI82 Received 27 February 2007 Revised 13 July 2007 Accepted 4 September 2007 2007 Sun et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Aspergillus niger is an important industrial microorganism for the production of both metabolites such as citric acid and proteins such as fungal enzymes or heterologous proteins. Despite its extensive industrial applications the genetic inventory of this fungus is only partially understood. The recently released genome sequence opens a new horizon for both scientific studies and biotechnological applications. Results Here we present the first genome-scale metabolic network for A. niger and an in-depth genomic comparison of this species to seven other fungi to disclose its metabolic peculiarities. The raw genomic sequences of A. niger ATCC 9029 were first annotated. The reconstructed metabolic network is based on the annotation of two A. niger genomes CBS and ATCC 9029 including enzymes with 988 unique EC numbers 2 443 reactions and 2 349 metabolites. More than I I00 enzyme-coding genes are unique to A. niger in comparison to the other seven fungi.
