Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex. | Open Access Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex Shuzhang YangH Kai WangH Otto Valladares Sridhar Hannenhalli and Maja Bucan Address Department of Genetics and Penn Center for Bioinformatics University of Pennsylvania Philadelphia PA 19104 USA. H These authors contributed equally to this work. Correspondence Maja Bucan. Email bucan@ Published 20 November 2007 Genome Biology 2007 8 R247 doi gb-2007-8- II-r247 The electronic version of this article is the complete one and can be found online at http 2007 8 II R247 Received 6 July 2007 Revised 5 October 2007 Accepted 20 November 2007 2007 Yang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system by sleep wake states or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances. Results We examined gene expression in the mouse prefrontal cortex at four time points during a 24 hour I2 hour light I2 hour dark cycle using microarrays and identified 3 890 transcripts corresponding to 2 927 genes with diurnally regulated expression patterns. We show that I6 of the genes identified in our study are orthologs of identified clock clock controlled or sleep wakefulness induced genes in the mouse liver and suprachiasmatic nucleus rat cortex and cerebellum or Drosophila head. The diurnal expression .
