Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. | Open Access Research Integrative analysis for finding genes and networks involved in diabetes and other complex diseases Regine Bergholdt Zenia M St0rlingHt Kasper LageHt E Olof Karlberg Páll Í Òlasonỷ Mogens Aalund J0rn Nerup S0ren BrunaV Christopher T Workman and Flemming Pociot Addresses Steno Diabetes Center Niels Steensensvej 2 DK-2820 Gentofte Denmark. Center for Biological Sequence Analysis Technical University of Denmark DK-2800 Lyngby Denmark. Neurotech A S DK-2100 Copenhagen Denmark. institute for Clinical Science University of Lund SE-221 00 Lund Sweden. n These authors contributed equally to this work. Correspondence Flemming Pociot. Email fpoc@ Published 28 November 2007 Genome Biology 2007 8 R253 doi gb-2007-8-ll-r253 The electronic version of this article is the complete one and can be found online at http 2007 8 ll R253 Received 7 July 2007 Revised 3l October 2007 Accepted 28 November 2007 2007 Bergholdt et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have developed an integrative analysis method combining genetic interactions identified using type l diabetes genome scan data and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes proteins for type l diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases. Background Complex traits like type 1 diabetes T1D are generally believed to be under the influence of multiple genes interacting with each other to confer .
