Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The reticulons: a family of proteins with diverse functions. | Protein family review The reticulons a family of proteins with diverse functions Yvonne S Yang and Stephen M Strittmatter Address Program in Cellular Neuroscience Neurodegeneration and Repair Department of Neurology Yale University School of Medicine New Haven Ct 06536 USA. Correspondence Stephen M Strittmatter. Email Published 28 December 2007 Genome Biology 2007 8 234 doi gb-2007-8-l2-234 The electronic version of this article is the complete one and can be found online at http 2007 8 12 234 2007 BioMed Central Ltd Summary The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon homology domain that consists of two hydrophobic regions flanking a hydrophilic loop of 60-70 amino acids but reticulon amino-terminal domains display little or no similarity to each other. Reticulons principally localize to the endoplasmic reticulum and there is evidence that they influence endoplasmic reticulum-Golgi trafficking vesicle formation and membrane morphogenesis. However mammalian reticulons have also been found on the cell surface and mammalian reticulon 4 expressed on the surface of oligodendrocytes is an inhibitor of axon growth both in culture and in vivo. There is also growing evidence that reticulons may be important in neurodegenerative diseases such as Alzheimer s disease and amyotrophic lateral sclerosis. The diversity of structure topology localization and expression patterns of reticulons is reflected in their multiple diverse functions in the cell. Gene organization and evolutionary history Proteins of the reticulon family are present in all eukaryotic organisms examined and range in size from 200 to 1 200 amino acids. The vertebrate proteins of this family are called reticulons RTNs and those found in other eukaryotes are called reticulon-like proteins RTNLs . All family members contain .
