Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genomic chart guiding embryonic stem cell cardiopoiesis. | Research Open Access Genomic chart guiding embryonic stem cell cardiopoiesis Randolph S Faustino Atta Behfar Carmen Perez-Terzic and Andre Terzic Addresses Marriott Heart Disease Research Program Division of Cardiovascular Diseases Departments of Medicine Molecular Pharmacology and Experimental Therapeutics and Medical Genetics Mayo Clinic First Street SW Rochester Minnesota 55905 USA. Department of Physical Medicine and Rehabilitation Mayo Clinic First Street SW Rochester Minnesota 55905 USA. Correspondence Andre Terzic. Email Published 9 January 2008 Genome Biology 2008 9 R6 doi gb-2008-9-1-r6 The electronic version of this article is the complete one and can be found online at http 2008 9 1 R6 Received 27 September 2007 Revised 20 November 2007 Accepted 9 January 2008 2008 Faustino et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Embryonic stem cells possess a pluripotent transcriptional background with the developmental capacity for distinct cell fates. Simultaneous expression of genetic elements for multiple outcomes obscures cascades relevant to specific cell phenotypes. To map molecular patterns critical to cardiogenesis we interrogated gene expression in stem cells undergoing guided differentiation and defined a genomic paradigm responsible for confinement of pluripotency. Results Functional annotation analysis of the transcriptome of differentiating embryonic stem cells exposed downregulated components of DNA replication recombination and repair machinery cell cycling cancer mechanisms and RNA post-translational modifications. Concomitantly cardiovascular development cell-to-cell signaling cell development and cell movement were upregulated.
