Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The SeqFEATURE library of 3D functional site models: comparison to existing methods and applications to protein function annotation. | Open Access The SeqFEATURE library of 3D functional site models comparison to existing methods and applications to protein function annotation Shirley Wu Mike P Liang and Russ B Altman Addresses Program in Biomedical Informatics Stanford University Stanford CA 94305 USA. tGoogle Inc. Amphitheatre Pkwy Mountain View CA 94043 USA. Department of Genetics Stanford University Stanford CA 94305 USA. Department of Bioengineering Stanford University Stanford CA 94305 USA. Correspondence Russ B Altman. Email Published 16 January 2008 Genome Biology 2008 9 R8 doi gb-2008-9-1-r8 The electronic version of this article is the complete one and can be found online at http content 9 1 R8 Received 1 August 2007 Revised 21 November 2007 Accepted 16 January 2008 2008 Wu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Structural genomics efforts have led to increasing numbers of novel uncharacterized protein structures with low sequence identity to known proteins resulting in a growing need for structurebased function recognition tools. Our method SeqFEATURE robustly models protein functions described by sequence motifs using a structural representation. We built a library of models that shows good performance compared to other methods. In particular SeqFEATURE demonstrates significant improvement over other methods when sequence and structural similarity are low. Background With the complete genomes sequenced for an increasing number of organisms emphasis is shifting from identifying genes and gene products to understanding protein function and the interactions between biological entities on a systems level. Molecular-level descriptions of cellular physiology are critical for
