Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Deceased donor neutrophil gelatinase-associated lipocalin and delayed graft function after kidney transplantation: a prospective study. | Hollmen et al. Critical Care 2011 15 R121 http content 15 3 R121 KS CRITICAL CARE RESEARCH Open Access Deceased donor neutrophil gelatinase-associated lipocalin and delayed graft function after kidney transplantation a prospective study 1 1 2 2 3 1 Maria E Hollmen Lauri E Kyllonen Kaija A Inkinen Martti LT Lalla Jussi Merenmies and Kaija T Salmela Abstract Introduction Expanding the criteria for deceased organ donors increases the risk of delayed graft function DGF and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocalin NGAL a novel biomarker for acute kidney injury could predict DGF after transplantation. Methods We included 99 consecutive deceased donors and their 176 kidney recipients. For NGAL detection donor serum and urine samples were collected before the donor operation. The samples were analyzed using a commercial enzyme-linked immunosorbent assay kit serum and the ARCHITECT method urine . Results Mean donor serum NGAL S-NGAL concentration was 218 ng mL range 27 to 658 standard deviation SD and mean donor urine NGAL U-NGAL concentration was 18 ng mL range 0 to 177 SD . Donor S-NGAL and U-NGAL concentrations correlated directly with donor plasma creatinine levels and indirectly with estimated glomerular filtration rate eGFR calculated using the modification of diet in renal disease equation for glomerular filtration rate. In transplantations with high greater than the mean donor U-NGAL concentrations prolonged DGF lasting longer than 14 days occurred more often than in transplantations with low less than the mean U-NGAL concentration 23 vs. 11 P and 1-year graft survival was worse vs. P . High U-NGAL concentration was also associated with significantly more histological changes in the donor kidney biopsies than the low U-NGAL concentration. In a multivariate analysis U-NGAL expanded criteria donor status and eGFR emerged as independent risk factors for .
