Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia. | Póvoa et al. Critical Care 2011 15 R129 http content 15 3 R129 KS CRITICAL CARE RESEARCH Open Access C-reactive protein in critically ill cancer patients with sepsis influence of neutropenia Pedro Póvoa1 2 Vicente Ces Souza-Dantas3 Márcio Soares3 4 and Jorge IF Salluh3 4 Abstract Introduction Several biomarkers have been studied in febrile neutropenia. Our aim was to assess C-reactive protein CRP concentration in septic critically ill cancer patients and to compare those with and without neutropenia. Methods A secondary analysis of a matched case-control study conducted at an oncologic medical-surgical intensive care unit ICU was performed segregating patients with severe sepsis septic shock. The impact of neutropenia on CRP concentrations at admission and during the first week of ICU stay was assessed. Results A total of 154 critically ill septic cancer patients 86 with neutropenia and 68 without were included in the present study. At ICU admission the CRP concentration of neutropenic patients was significantly higher than in non-neutropenic patients mg dL vs. mg dL P . Among neutropenic patients CRP concentrations at ICU admission were not influenced by the severity of neutropenia 100 mm3 vs. 100 mm3 neutrophils mg dL vs. mg dL P . Time dependent analysis of CRP from Day 1 to Day 7 of antibiotic therapy showed an almost parallel decrease in both groups P though CRP of neutropenic patients was on average always higher in comparison to that of non-neutropenic patients. Conclusions In septic critically ill cancer patients CRP concentrations are more elevated in those with neutropenia. However the CRP course seems to be independent from the presence or absence of neutropenia. Introduction The frequency of cancer patients requiring intensive care has increased dramatically over the last decades 1 . Frequently in these patients combined mechanisms of immunosuppression coexist resulting in an .
