Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A computational model of gene expression reveals early transcriptional events at the subtelomeric regions of the malaria parasite, Plasmodium falciparum. | Open Access A computational model of gene expression reveals early transcriptional events at the subtelomeric regions of the malaria parasite Plasmodium falciparum Matthias Scholz and Martin J Fraunholz Address Competence Center for Functional Genomics Ernst-Moritz-Arndt University Friedrich-Ludwig-Jahn Strasse D-17487 Greifswald Germany. Correspondence Matthias Scholz. Email Published 27 May 2008 Genome Biology 2008 9 R88 doi 186 gb-2008-9-5-r88 The electronic version of this article is the complete one and can be found online at http 2008 9 5 R88 Received 25 January 2008 Revised 21 April 2008 Accepted 27 May 2008 2008 Scholz and Fraunholz licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The malaria parasite Plasmodium falciparum replicates asexually in a well-defined infection cycle within human erythrocytes red blood cells . The intra-erythrocytic developmental cycle IDC proceeds with a 48 hour periodicity. Results Based on available malaria microarray data which monitored gene expression over one complete IDC in one-hour time intervals we built a mathematical model of the IDC using a circular variant of non-linear principal component analysis. This model enables us to identify rates of expression change within the data and reveals early transcriptional events at the subtelomeres of the parasite s nuclear chromosomes. Conclusion A delay between subtelomeric and central gene activities suggests that key events of the IDC are initiated at the subtelomeric regions of the P. falciparum nuclear chromosomes. Background The protozoan parasite Plasmodium falciparum causes malaria in humans. The life cycle of Plasmodium includes multiple stages of .
