Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution. | Open Access The hidden universal distribution of amino acid biosynthetic networks a genomic perspective on their origins and evolution Georgina Hernández-MontesH J Javier Díaz-MejíaH Ỷ Ernesto Perez-Rueda and Lorenzo Segovia Addresses Departamento de Ingeniería Celular y Biocatálisis Instituto de Biotecnología Universidad Nacional Autónoma de México. Av. Universidad Col. Chamilpa Cuernavaca Morelos Mexico CP 62210. Department of Biology Wilfrid Laurier University University Av. Waterloo ON N2L 3C5 Canada and Donnelly Centre for Cellular and Biomolecular Research University of Toronto. College St. Toronto ON M5S 3E1 Canada. H These authors contributed equally to this work. Correspondence Lorenzo Segovia. Email lorenzo@ Published 9 June 2008 Genome Biology 2008 9 R95 doi 186 gb-2008-9-6-r95 The electronic version of this article is the complete one and can be found online at http 2008 9 6 R95 Received 4 December 2007 Revised 6 May 2008 Accepted 9 June 2008 2008 Hernández-Montes et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Twenty amino acids comprise the universal building blocks of proteins. However their biosynthetic routes do not appear to be universal from an Escherichia coli-centric perspective. Nevertheless it is necessary to understand their origin and evolution in a global context that is to include more model species and alternative routes in order to do so. We use a comparative genomics approach to assess the origins and evolution of alternative amino acid biosynthetic network branches. Results By tracking the taxonomic distribution of amino acid biosynthetic enzymes we predicted a core of widely distributed network branches biosynthesizing at least 16 .
