Báo cáo sinh học: " Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock | Genetics Selection Evolution BioMed Central Research Ovine progressive pneumonia provirus levels are unaffected by the prion I7IR allele in an Idaho sheep flock Robert D Harrington 1 2 3 Lynn M Herrmann-Hoesing1 2 Stephen N White1 2 4 Katherine I O Rourke1 2 and Donald P Knowles1 2 Open Access Address 1Animal Disease Research Unit Agricultural Research Service US Department of Agriculture Pullman WA 99164-6630 USA 2Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164-7040 USA 3Department of Comparative Medicine University of Washington Seattle WA 98195-7190 USA and 4Center for Integrated Biotechnology Washington State University Pullman WA 99164 USA Email Robert D Harrington - rdh@ Lynn M Herrmann-Hoesing-lherrman@ Stephen N White - swhite@ Katherine I O Rourke - korourke@ Donald P Knowles - dknowles@ Corresponding author Published 22 January 2009 Received 17 December 2008 Genetics Selection Evolution 2009 41 17 doi l297-9686-4l-l7 Accepted 22 January 2009 This article is available from http content 4l l l7 2009 Harrington et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Selective breeding of sheep for arginine R at prion gene PRNP codon l7l confers resistance to classical scrapie. However other effects of I7IR selection are uncertain. Ovine progressive pneumonia Maedi-Visna virus OPPV may infect up to 66 of a flock thus any affect of I7IR selection on OPPV susceptibility or disease progression could have major impact on the sheep industry. Hypotheses that the PRNP I7IR allele is l associated with the presence of OPPV provirus and 2 associated with higher provirus levels