Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Linear models for joint association and linkage QTL mapping | Genetics Selection Evolution BioMed Central Research Linear models for joint association and linkage QTL mapping Andrés Legarra 1 and Rohan L Fernando2 3 Open Access Address 1INRA UR631 BP 52627 31326 Castanet Tolosan France 2Department of Animal Science Iowa State University Ames IA USA and 3Center for Integrated Animal Genomics Iowa State University Ames IA USA Email Andrés Legarra - Rohan L Fernando - fernando@ Corresponding author Published 29 September 2009 Received 22 January 2009 - . Accepted 29 September 2009 Genetics Selection Evolution 2009 41 43 doi 1297-9686-41-43 This article is available from http content 41 1 43 2009 Legarra and Fernando licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Populational linkage disequilibrium and within-family linkage are commonly used for QTL mapping and marker assisted selection. The combination of both results in more robust and accurate locations of the QTL but models proposed so far have been either single marker complex in practice or well fit to a particular family structure. Results We herein present linear model theory to come up with additive effects of the QTL alleles in any member of a general pedigree conditional to observed markers and pedigree accounting for possible linkage disequilibrium among QTLs and markers. The model is based on association analysis in the founders further the additive effect of the QTLs transmitted to the descendants is a weighted by the probabilities of transmission average of the substitution effects of founders haplotypes. The model allows for non-complete linkage .
