Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Geographic distribution of haplotype diversity at the bovine casein locus | Genet. Sel. Evol. 36 2004 243-257 INRA EDP Sciences 2004 DOI gse 2003061 243 Original article Geographic distribution of haplotype diversity at the bovine casein locus Oliver C. jANNa Eveline M. lBEAGHA-AwEMUa Ceyhan OzBEYAZb Pilar Zaragozac John L. Williams Paolo AjMONE-MARSANe Johannes A. LENSTRAf Katy MoAZAMi-GouDARZig Georg ERHARDTa a Department for Animal Breeding and Genetics Justus-Liebig University of Giessen Germany b Department of Zootechnics Faculty of Veterinary Medicine University of Ankara Turkey c Laboratorio de Genetica Bioquimica y Grupos Sanguineos Facultad Veterinaria Zaragoza Spain dRoslin Institute Edinburgh Midlothian Scotland EH25 9PS UK e Institute of Zootechnics Catholic University of Sacred Heart Piacenza Italy f Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands g INRA-LGBC Domaine de Vilvert 78352 Jouy-en-Josas France Received 1 October 2002 accepted 10 September 2003 Abstract - The genetic diversity of the casein locus in cattle was studied on the basis of haplotype analysis. Consideration of recently described genetic variants of the casein genes which to date have not been the subject of diversity studies allowed the identification of new haplotypes. Genotyping of 30 cattle breeds from four continents revealed a geographically associated distribution of haplotypes mainly defined by frequencies of alleles at CSN1S1 and CSN3. The genetic diversity within taurine breeds in Europe was found to decrease significantly from the south to the north and from the east to the west. Such geographic patterns of cattle genetic variation at the casein locus may be a result of the domestication process of modern cattle as well as geographically differentiated natural or artificial selection. The comparison of African Bos taurus and Bos indicus breeds allowed the identification of several Bos indicus specific haplotypes CSN1S1 C-CSN2 A2-CSN3 ÁI CSN3 H that are not found in pure taurine breeds. The occurrence of such .
