Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Sustainable long-term conservation of rare cattle breeds using rotational AI sires | Genet. Sel. Evol. 40 2008 415-432 INRA EDP Sciences 2008 DOI gse 2008011 Available online at Original article Sustainable long-term conservation of rare cattle breeds using rotational AI sires Jean-Jacques Colleau1 Laurent Avon2 1INRA UR337 Station de génétique quantitative et appliquee 78352 Jouy-en-Josas Cedex France 2Institut de l elevage Departement Genetique 149 Rue de Bercy 75595 Paris Cedex 12 France Received 21 September 2007 accepted 30 January 2008 Abstract - The development of inbreeding in rotation breeding schemes sequentially using artificial insemination AI sires over generations was investigated for a full AI scheme. Asymptotic prediction formulae of inbreeding coefficients were established when the first rotation list of AI sires possibly related was in use. Simulated annealing provided the optimal rotation order of sires within this list when the sires were related. These methods were also used for subsequent rotation lists needed by the exhaustion of semen stores for the first bulls. Simulation was carried out starting with groups of independent sires with different sizes. To generate a yearly inbreeding rate substantially lower than considered to be within reach by conventional conservation schemes using frequent replacements the results obtained showed that the number of sires should be at least 10-15 and that the same sires should be used during at least 50 years. The ultimate objective was to examine the relevance of implementing rotation in breeding schemes on the actual rare French cattle breeds under conservation. The best candidate for such a test was the Villard-de-Lans breed 27 bulls and 73 000 doses for only 340 females and it turned out to be the best performer with an inbreeding coefficient of only after 500 years and five different sire lists. Due to the strong requirements on semen stores and on the stability of population size actual implementation of this kind of conservation scheme was .