Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. | Research Open Access Computational identification of developmental enhancers conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura Benjamin P BermanH Barret D PfeifferH Todd R Laverty Steven L Salzberg Gerald M Rubin Michael B EisenH and Susan E CelnikerH Addresses Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. Berkeley Drosophila Genome Project Genome Sciences Department Life Sciences Division Lawrence Orlando Berkeley National Laboratory Berkeley CA 94720 USA. Howard Hughes Medical Institute Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. The Institute for Genomic Research 9712 Medical Center Drive Rockville MD 20878 USA. Genome Sciences Department Genomics Division Lawrence Orlando Berkeley National Laboratory Berkeley CA 94720 USA. Center for Integrative Genomics University of California Berkeley CA 94720 USA. H These authors contributed equally to this work. Correspondence Michael B Eisen. E-mail mbeisen@ Published 20 August 2004 Genome Biology 2004 5 R61 The electronic version of this article is the complete one and can be found online at http 2004 5 9 R61 Received 14 July 2004 Revised 4 August 2004 Accepted 6 August 2004 2004 Berman et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The identification of sequences that control transcription in metazoans is a major goal of genome analysis. In a previous study we demonstrated that searching for clusters of predicted transcription factor binding sites could discover active regulatory sequences and identified 37 regions of the Drosophila melanogaster genome with high .
