Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Discovery of estrogen receptor α target genes and response elements in breast tumor cells. | Research Open Access Discovery of estrogen receptor a target genes and response elements in breast tumor cells Chin-Yo Lin Anders Strom Vinsensius Berlian Vega Say Li Kong Ai Li Yeo Jane S Thomsen Wan Ching Chan Balraj Doray Dhinoth K Bangarusamy Adaikalavan Ramasamy Liza A Vergara Suisheng Tang Allen Chong Vladimir B Bajic Lance D Miller Jan-Ẳke Gustafsson and Edison T Liu Addresses Genome Institute of Singapore Singapore 117528. Center for Biotechnology Karolinska Institute Novum S-141 57 Huddinge Sweden. Knowledge Extraction Lab Institute for Infocomm Research Singapore 119613 . Department of Medical Nutrition Karolinska Institute Novum S-141 86 Huddinge Sweden. Correspondence Chin-Yo Lin. E-mail lincy@. Edison T Liu. E-mail liue@ Received 29 March 2004 Revised 4 June 2004 Accepted 15 July 2004 Published 12 August 2004 Genome Biology 2004 5 R66 The electronic version of this article is the complete one and can be found online at http 2004 5 9 R66 2004 Lin et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Estrogens and their receptors are important in human development physiology and disease. In this study we utilized an integrated genome-wide molecular and computational approach to characterize the interaction between the activated estrogen receptor ER and the regulatory elements of candidate target genes. Results Of around 19 000 genes surveyed in this study we observed I 37 ER-regulated genes in T-47D cells of which only 89 were direct target genes. Meta-analysis of heterogeneous in vitro and in vivo datasets showed that the expression profiles in T-47D and MCF-7 cells are remarkably similar and overlap with genes differentially expressed .
