Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum. | Research Open Access Phylogenomic evidence supports past endosymbiosis intracellular and horizontal gene transfer in Cryptosporidium parvum Jinling Huang Nandita Mullapudi Cheryl A Lancto Marla Scott Mitchell S Abrahamsen and Jessica C Kissinger Addresses Center for Tropical and Emerging Global Diseases University of Georgia Athens GA 30602 USA. Department of Genetics University of Georgia Athens GA 30602 USA. Veterinary and Biomedical Sciences University of Minnesota St Paul MN 55108 USA. Correspondence Jessica C Kissinger. E-mail jkissing@ Published 19 October 2004 Genome Biology 2004 5 R88 The electronic version of this article is the complete one and can be found online at http 2004A5 11 R88 Received 19 April 2004 Revised 16 August 2004 Accepted 10 September 2004 2004 Huang et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The apicomplexan parasite Cryptosporidium parvum is an emerging pathogen capable of causing illness in humans and other animals and death in immunocompromised individuals. No effective treatment is available and the genome sequence has recently been completed. This parasite differs from other apicomplexans in its lack of a plastid organelle the apicoplast. Gene transfer either intracellular from an endosymbiont donor organelle or horizontal from another organism can provide evidence of a previous endosymbiotic relationship and or alter the genetic repertoire of the host organism. Given the importance of gene transfers in eukaryotic evolution and the potential implications for chemotherapy it is important to identify the complement of transferred genes in Cryptosporidium. Results We have identified 31 genes of likely plastid endosymbiont n 7 or .
