Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The ASRG database: identification and survey of Arabidopsis thaliana genes involved in pre-mRNA splicing. | Software Open Access The ASRG database identification and survey of Arabidopsis thaliana genes involved in pre-mRNA splicing Bing-Bing Wang and Volker Brender Addresses Department of Genetics Development and Cell Biology Iowa State University Ames IA 50011-3260 USA. Department of Statistics Iowa State University Ames IA 50011-3260 USA. Correspondence Volker Brendel. E-mail vbrendel@ Published 29 November 2004 Genome Biology 2004 5 The electronic version of this article is the complete one and can be found online at http 2004 5 12 R102 Received 25 June 2004 Revised 6 September 2004 Accepted 20 October 2004 2004 Wang and Brendel licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A total of 74 small nuclear RNA snRNA genes and 395 genes encoding splicing-related proteins were identified in the Arabidopsis genome by sequence comparison and motif searches including the previously elusive U4atac snRNA gene. Most of the genes have not been studied experimentally. Classification of these genes and detailed information on gene structure alternative splicing gene duplications and phylogenetic relationships are made accessible as a comprehensive database of Arabidospis Splicing Related Genes ASRG on our website. Rationale Most eukaryotic genes contain introns that are spliced from the precursor mRNA pre-mRNA . The correct interpretation of splicing signals is essential to generate authentic mature mRNAs that yield correct translation products. As an important post-transcriptional mechanism gene function can be controlled at the level of splicing through the production of different mRNAs from a single pre-mRNA reviewed in 1 . The general mechanism of splicing has been well studied in human and .
