Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Histones: should I stay or should I go? | Meeting report Histones should I stay or should I go Bing Li Chun Ruan and Jerry L Workman Addresses Stowers Institute for Medical Research 1 000 East 50th Street Kansas City MO 64110 USA. The Huck Institute of the Life Sciences Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA 16802 USA. Correspondence Bing Li. E-mail bli@ Published 14 January 2005 Genome Biology 2005 6 306 The electronic version of this article is the complete one and can be found online at http 2005 6 2 306 2005 BioMed Central Ltd A report on the American Society for Biochemistry and Molecular Biology symposium Transcriptional Regulation by Chromatin and RNA polymerase II Lake Tahoe USA 29 October-1 November 2004. This year s American Society for Biochemistry and Molecular Biology symposium on transcription covered a wide variety of topics ranging from chromatin regulation through the initiation of transcription and elongation process during transcription by RNA polymerase II Pol II to the roles of signaling in transcription and development. This report focuses on the sessions on chromatin which led to many insightful discussions as a consequence of the rapid advances in this field over the past few years. Direct and indirect functions of histone modifications A central role for chromatin in regulating processes such as transcription and replication is now widely recognized. It is generally believed that the dynamic regulation of chromatin structure makes use of a diverse repertoire of post-translational histone modifications ATP-dependent chromatin remodeling and histone-variant exchange. Prevailing views on histone modification and its consequences for the modulation of chromatin dynamics as proposed in the histone code hypothesis suggest that combinations of covalent modifications of specific histone residues comprise a structural and chemical code that can be recognized by other protein modules which .
