Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae. | Research Open Access Comparison of the oxidative phosphorylation OXPHOS nuclear genes in the genomes of Drosophila melanogaster Drosophila pseudoobscura and Anopheles gambiae Gaetano Tripoli Domenica D Elia Paolo Barsanti and Corrado Caggese Addresses University of Bari DAPEG Section of Genetics via Amendola 165 A 70126 Bari Italy. CNR Institute of Biomedical Technology Section of Bari via Amendola 122 D 70126 Bari Italy. Correspondence Corrado Caggese. E-mail caggese@ Published 31 January 2005 Genome Biology 2005 6 R1 1 The electronic version of this article is the complete one and can be found online at http 2005 6 2 R11 Received 24 September 2004 Revised 8 December 2004 Accepted 7 January 2005 2005 Tripoli et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In eukaryotic cells oxidative phosphorylation OXPHOS uses the products of both nuclear and mitochondrial genes to generate cellular ATP. Interspecies comparative analysis of these genes which appear to be under strong functional constraints may shed light on the evolutionary mechanisms that act on a set of genes correlated by function and subcellular localization of their products. Results We have identified and annotated the Drosophila melanogaster D. pseudoobscura and Anopheles gambiae orthologs of 78 nuclear genes encoding mitochondrial proteins involved in oxidative phosphorylation by a comparative analysis of their genomic sequences and organization. We have also identified 47 genes in these three dipteran species each of which shares significant sequence homology with one of the above-mentioned OXPHOS orthologs and which are likely to have originated by duplication during evolution. Gene structure and .
