Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Protein degradation, signaling, microRNAs and cancer. | Meeting report Protein degradation signaling microRNAs and cancer Peter Gallant Address Zoologisches Institut Universitat Zurich Winterthurerstrasse 190 8057 Zurich Switzerland. E-mail gallant@ Published 31 March 2005 Genome Biology 2005 6 316 doi gb-2005-6-4-3l6 The electronic version of this article is the complete one and can be found online at http 2005 6 4 316 2005 BioMed Central Ltd A report on the biannual Swiss Institute for Experimental Cancer Research ISREC Symposium on the Cell and Molecular Biology of Cancer Lausanne Switzerland 19-22 January 2005. Every two years biologists and oncologists gather in Lausanne on the shores of Lake Geneva to discuss the latest advances in research into the cell and molecular biology of cancer. Presentations at the most recent of these meetings covered a wide range of topics a small selection of which is described here. Several talks were devoted to the cellular protein degradation machinery and its targets in the cell cycle. The protein p27 is an inhibitor of the kinase activity of the complex of cyclin-dependent kinase Cdk2 and cyclin E and the destruction of p27 is normally required before a cell can enter S phase of the cell cycle. An essential role in p27 degradation has been assigned to the E3 ubiquitin ligase SCF-Skp2 named after its components skp1 cullin and F-box protein . Willy Krek Eid-genossische Technische Hochschule Zurich Switzerland confirmed the importance of Skp2 in p27 degradation but presented the audience with a new ubiquitin-ligase partner for Skp2 a RING-domain containing protein called SAR1 Skp2-associated RBCC protein 1 that belongs to the RBCC ring finger B box coiled-coil family. Both SAR1 and Skp2 are found in a complex with Cul1 a core subunit also found in SCF and the whole complex has been baptized CRF-Skp2 for Cul1-RBCC-F-box complex containing Skp2 . Specific inhibition of CRF-Skp2 results in accumulation of p27 in particular of the form .
