Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: L2L: a simple tool for discovering the hidden significance in microarray expression data. | Open Access Software L2L a simple tool for discovering the hidden significance in microarray expression data John C Newman and Alan M Weiner Address Department of Biochemistry University of Washington Seattle WA 98115 USA. Correspondence John C Newman. E-mail newmanj@ Published 31 August 2005 Genome Biology 2005 6 R81 doi 186 gb-2005-6-9-r81 The electronic version of this article is the complete one and can be found online at http 2005 6 9 R81 Received 5 April 2005 Revised 16 June 2005 Accepted 26 July 2005 2005 Newman and Weiner licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract L2L is a database consisting of lists of differentially expressed genes compiled from published mammalian microarray studies along with an easy-to-use application for mining the database with the user s own microarray data. As illustrated by re-analysis of a recent study of diabetic nephropathy L2L identifies novel biological patterns in microarray data providing insights into the underlying nature of biological processes and disease. L2L is available online at the authors website http l2l . Rationale In only a few years since their development high-throughput whole-genome DNA microarrays have become an invaluable tool throughout biology. The appeal of microarrays seems most irresistible when the biological problem is most intractable microarrays have become perhaps the most popular contemporary tool for hypothesis generation. Yet interpreting the mountain of data produced by a microarray experiment can be a frustrating chore. The most common outcome of such an experiment is a list of genes or many such lists genes that are induced or repressed under one condition or another at one .
