Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Large-scale approaches for glycobiology. | Review Large-scale approaches for glycobiology Christopher T Campbell and Kevin J Yarema Address Department of Biomedical Engineering The Johns Hopkins University 3400 North Charles Street Baltimore MD 21218 USA. Correspondence Kevin J Yarema. E-mail kyarema1@ Published 3 November 2005 Genome Biology 2005 6 236 doi gb-2005-6-ll-236 The electronic version of this article is the complete one and can be found online at http 2005 6 ll 236 2005 BioMed Central Ltd Abstract Glycosylation the attachment of carbohydrates to proteins and lipids influences many biological processes. Despite detailed characterization of the cellular components that carry out glycosylation a complete picture of a cell s glycoconjugates remains elusive because of the challenges inherent in characterizing complex carbohydrates. This article reviews large-scale techniques for accelerating progress in glycobiology. The problem with sugars Glycobiology - the study of carbohydrates in biology - combines expertise in synthetic and analytical chemistry and carbohydrate biochemistry as well as molecular and cellular biology to unravel the structural complexity chemistry biosynthesis and biological functions of sugar-bearing biomolecules. Over the past three decades complex carbohydrates have become widely recognized as more than just an energy source 1 . Indeed glycosylation has been established as a ubiquitous post-translational modification in higher organisms that enables one protein or lipid to function as many and provides structural diversity that offers an explanation for the unexpectedly low number of genes in the human genome 2 . Complex sugars are major players in numerous biological processes including developmental biology the immune response and inflammatory disease cell proliferation and apoptosis the pathogenesis of infectious agents including prions viruses and bacteria and a wide range of diseases ranging from rare congenital disorders to diabetes and .
