Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Virus-host interactions: new insights from the small RNA world. | Minireview Virus-host interactions new insights from the small RNA world Edward P Browne Junjie Li Mark Chong and Dan R Littman Addresses Molecular Pathogenesis Program and Howard Hughes Medical Institute Skirball Institute of Biomolecular Medicine New York University School of Medicine New York NY 10016 USA. Correspondence Dan R Littman. E-mail littman@. Edward P Browne. E-mail browne@ Published 31 October 2005 Genome Biology 2005 6 238 doi gb-2005-6-ll-238 The electronic version of this article is the complete one and can be found online at http 2005 6 ll 238 2005 BioMed Central Ltd Abstract RNA silencing has a known role in the antiviral responses of plants and insects. Recent evidence including the finding that the Tat protein of human immunodeficiency virus HIV can suppress the host s RNA-silencing pathway and may thus counteract host antiviral RNAs suggests that RNA-silencing pathways could also have key roles in mammalian virus-host interactions. Over the course of evolution viruses have developed highly sophisticated mechanisms for interacting with host cells. Such interactions may involve parasitizing the cellular machinery to enhance the production of progeny viruses budding of virions of the human immunodeficiency virus HIV for example makes use of the endosomal sorting complexes ESCRT complexes that normally regulate the formation of the multivesicular bodies of the endosomal pathway 1 . In addition many viruses have mechanisms for disrupting the immune response to viral infection. An example is the inhibition by the human cytomegalovirus proteins US2 and US11 of the presentation of antigens by host MHC class I molecules this prevents the recognition and destruction of virus-infected cells by the host immune system 2 . New research is now beginning to show that the complex interaction between viruses and host cells also involves RNA-silencing pathways. RNA silencing in animal cells is carried
