Báo cáo y học: "Ulysses - an application for the projection of molecular interactions across species"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Ulysses - an application for the projection of molecular interactions across species. | Software Open Access Ulysses - an application for the projection of molecular interactions across species Danielle Kemmer 1 Yong Huang Sohrab P Shah Jonathan Lim Jochen Brumm Macaire MS Yuen John Ling Tao Xu Wyeth W Wasserman and BF Francis Ouellette Addresses Center for Genomics and Bioinformatics Karolinska Institutet 171 77 Stockholm Sweden. Centre for Molecular Medicine and Therapeutics University of British Columbia Vancouver V5Z 4H4 BC Canada. UBC Bioinformatics Centre University of British Columbia Vancouver V6T 1Z4 BC Canada. Department of Medical Genetics University of British Columbia Vancouver BC Canada. Michael Smith Laboratories University of British Columbia Vancouver V6T 1Z4 BC Canada. Department of Computer Science University of British Columbia Vancouver V6T 1Z4 BC Canada. Correspondence WyethW Wasserman. E-mail wyeth@ Published 2 December 2005 Genome Biology 2005 6 Rl06 doi gb-2005-6-l2-rl06 The electronic version of this article is the complete one and can be found online at http 2005 6 l2 Rl06 Received 23 February 2005 Revised 3 August 2005 Accepted 8 November 2005 2005 Kemmer et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to perform such Interolog Analysis by the projection of model organism interaction data onto homologous human proteins and thus serves as an accelerator for the analysis of uncharacterized human proteins. The relevance of projections was assessed and validated against published reference collections. All source code is freely .

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