Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Functional genomics of early cortex patterning. | Minireview Functional genomics of early cortex patterning David Chambers and Gord Fishell Addresses Wellcome Trust Functional Genomics Development Initiative MRC Centre for Developmental Neurobiology King s College London Guy s Campus London SE1 1UL UK. Developmental Genetics Program and the Department of Cell Biology Skirball Institute of Biomolecular Medicine New York University Medical Center 550 First Avenue New York NY 10016 USA. Correspondence David Chambers. Email Published 31 January 2006 Genome Biology 2006 7 202 doi gb-2006-7-l-202 The electronic version of this article is the complete one and can be found online at http 2006 7 1 202 2006 BioMed Central Ltd Abstract Several lines of evidence have illuminated the fundamental developmental principles involved in establishing and implementing pattern formation in the mammalian neocortex. A recent study has sought to unravel the underlying genetic control of cortex patterning by elucidating the transcriptional profile of discrete neocortical regions. Patterning the neocortex The cerebral cortex where the higher brain functions reside is an exquisitely patterned structure composed of numerous specialized areas that subserve sensory motor and cognitive modalities for overview see 1 . This is achieved through the cortex being iteratively organized into discrete functional columns each of which has a laminar organization. Elucidating the mechanisms that govern the initial divisions of the cerebral cortex into these morphological and anatomically distinct areas and determining the means by which these columns subsequently become organized into functionally specialized units represents some of the key goals in developmental neurobiology. Considerable evidence suggests that final specification of areal territories within the cortex can be explained by a composite of the two prevailing models known as the protomap 2 and protocortex hypotheses 3 for review see 4 . .
