Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The dynamic proteome of Lyme disease Borrelia. | Minireview The dynamic proteome of Lyme disease Borrelia Steven J Norris Address Departments of Pathology and Laboratory Medicine and Microbiology and Molecular Genetics University of Texas Medical School Houston TX 77225-0708 USA. Email Published 17 March 2006 Genome Biology 2006 7 209 doi gb-2005-7-3-209 The electronic version of this article is the complete one and can be found online at http 2005 7 3 209 2006 BioMed Central Ltd Abstract The proteome of the spirochete bacterium Borrelia burgdorferi the tick-borne agent of Lyme disease has been characterized by two different approaches using mass spectrometry providing a launching point for future studies on the dramatic changes in protein expression that occur during transmission of the bacterium between ticks and mammals. We have all experienced it the deer in the headlights sensation of dumbfounded wonderment and awe when confronted with our first genome sequence. This is a particularly likely response to the genome of the spirochete Borrelia burgdorferi and its relatives - spiral bacteria that are transmitted by deer ticks of the Ixodes ricinus group and that cause the chronic disease Lyme borreliosis in humans and other animals. Although there were previous indications of its unusual characteristics no one anticipated that the megabase genome of B. burgdorferi would contain an odd mixture of approximately 12 linear and 9 circular plasmids as well as a megabase linear chromosome 1 2 . The plasmids which range from 5 to 56 kilobases are present consistently in the strains examined so far and contain genes required for the spirochete s life cycle these replicons thus could be considered mini-chromosomes although the term plasmids is typically used for simplicity. The 833 predicted plasmid-encoded open reading frames ORFs include 454 hypothetical genes many of which are members of 107 par-alogous families of unknown function. The plasmids are also .
