Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The contributions of normal variation and genetic background to mammalian gene expression. | Research Open Access The contributions of normal variation and genetic background to mammalian gene expression Colin Pritchard David Coil Sarah Hawley Li Hsu and Peter S Nelson Addresses Divisions of Human Biology Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Clinical Research Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Correspondence Peter S Nelson. Email pnelson@ Published 31 March 2006 Genome Biology 2006 7 R26 doi 186 gb-2006-7-3-r26 The electronic version of this article is the complete one and can be found online at http 2006 7 3 R26 Received 22 September 2005 Revised 19 December 2005 Accepted 28 February 2006 2006 Pritchard et al. licensee BioMed Central Ltd. This is an open access article ditributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribtion and reproduction in any medium provided the original work is properly cited. Abstract Background Qualitative and quantitative variability in gene expression represents the substrate for external conditions to exert selective pressures for natural selection. Current technologies allow for some forms of genetic variation such as DNA mutations and polymorphisms to be determined accurately on a comprehensive scale. Other components of variability such as stochastic events in cellular transcriptional and translational processes are less well characterized. Although potentially important the relative contributions of genomic versus epigenetic and stochastic factors to variation in gene expression have not been quantified in mammalian species. Results In this study we compared microarray-based measures of hepatic transcript abundance levels within and between five different strains of Mus musculus. Within each strain 23 to 44 of all genes exhibited statistically significant .
