Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Circadian rhythms lit up in Chlamydomonas. | Minireview Circadian rhythms lit up in Chlamydomonas Ghislain Breton and Steve A Kay Address The Scripps Research Institute Biochemistry Department 10550 N. Torrey Pines Road La Jolla CA 92037 USA. Correspondence Steve A Kay. Email stevek@ Published 28 April 2006 Genome Biology 2006 7 215 doi gb-2006-7-4-215 The electronic version of this article is the complete one and can be found online at http 2006 7 4 215 2006 BioMed Central Ltd Abstract Recent work on the circadian clock of the unicellular green alga Chlamydomonas reinhardtii strengthens its standing as a convenient model system for circadian study. It was shown to be amenable to molecular engineering using a luciferase-based real-time reporter for circadian rhythms. Together with the completed draft genomic sequence the new system opens the door for genome-scale forward and reverse genetic analysis. Chlamydomonas reinhardtii is often referred to as green yeast to convey the usefulness of this eukaryotic unicellular green alga as a model organism for plant research 1 . Like a plant cell Chlamydomonas possesses a cell wall and a chloroplast but like animal sperm cells it has a flagellum. This structure enables it to carry out phototaxis moving towards or away from light and so maximizing light perception for photosynthesis and minimizing photodamage. When given a light source C. reinhardtii can be grown in large quantities in a simple medium containing only inorganic salts. In the dark it can also grow non-photosynthetically with acetate as its sole carbon source. As most of its life cycle is in the haploid phase C. reinhardtii is amenable to genetic screens which have led to major discoveries in the fields of chloroplast biogenesis and the structure of eukaryotic flagella and the basal bodies from which they derive 2 . In the past decade the C. reinhardtii community has embraced the genomic revolution 3 . In addition to the mitochondrial and chloroplast genomes the 110 Mb
