Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. | Research Open Access Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins Jay R Hesselberth John P Miller Anna Golob Jason E Stajich Gregory A Michaud and Stanley Fields Addresses Department of Genome Sciences University of Washington Box 357730 Seattle WA 98195 USA. Department of Molecular Genetics and Microbiology Duke University Durham NC 27710 USA. Invitrogen East Main Street Branford CT 06405 USA. Department of Medicine and Howard Hughes Medical Institute University of Washington Box 357730 Seattle WA 98195 USA. Current address Buck Institute Redwood Boulevard Novato CA 94945 USA. H These authors contributed equally to this work. Correspondence Stanley Fields. Email fields@ Published 10 April 2006 Genome Biology 2006 7 R30 doi 186 gb-2006-7-4-r30 The electronic version of this article is the complete one and can be found online at http 2006 7 4 R30 Received 22 November 2005 Revised 10 February 2006 Accepted 9 March 2006 2006 Hesselberth et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The WW domain is found in a large number of eukaryotic proteins implicated in a variety of cellular processes. WW domains bind proline-rich protein and peptide ligands but the protein interaction partners of many WW domain-containing proteins in Saccharomyces cerevisiae are largely unknown. Results We used protein microarray technology to generate a protein interaction map for 12 of the 13 WW domains present in proteins of the yeast S. cerevisiae. We observed 587 interactions between these 12 domains and 207 proteins most of which have not previously been described. We analyzed the representation of functional annotations within the .
