Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Systems biology of gene regulation fulfills its promise. | Meeting report Systems biology of gene regulation fulfills its promise Adrienne E McKee and Pamela A Silver Address Department of Systems Biology Harvard Medical School Boston MA 02115 USA. Correspondence Pamela Silver. Email pamela_silver@ Published 22 May 2006 Genome Biology 2006 7 316 doi gb-2006-7-5-3l6 The electronic version of this article is the complete one and can be found online at http 2006 7 5 316 2006 BioMed Central Ltd A report on the meeting Systems Biology Global Regulation of Gene Expression at Cold Spring Harbor New York USA 23-26 March 2006. A systems-level understanding of gene-regulation programs requires the synthesis of biological computational mathematical and engineering approaches. One aim of a recent meeting on gene expression at the Cold Spring Harbor Laboratory was to promote this synthesis by bringing together experimentalists and computational biologists with a common interest in studying the organization and control of expression in complex biological systems. The presentations largely focused on identification and analysis of protein-DNA interactions the discovery of cis-regulatory motifs and the application of systems approaches to the study of post-transcriptional processes. Here we report on some of the remarkable experimental and computational advances in understanding gene regulation discussed at the meeting. A full list of abstracts is available at http . edu meetings abstracts . Studying genome occupancy and protein-DNA interactions Chromatin immunoprecipitation followed either by DNA hybridization to microarrays ChIP-chip or by DNA sequencing of paired end tags ChIP-PET are two widely used approaches to map protein interactions with the genome. One focus of the meeting was on the data obtained from these genome-occupancy studies. Several presentations showed that researchers are expanding the analysis of genome occupancy to tissue and .
