Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Splicing bioinformatics to biology. | Meeting report Splicing bioinformatics to biology Douglas L Black and Brenton R Graveley Addresses Department of Microbiology Immunology and Molecular Genetics Howard Hughes Medical Institute University of California Los Angeles CA 90095-1662 USA. Department of Genetics and Developmental Biology University of Connecticut Health Center 263 Farmington Avenue Farmington CT 06030-3301 USA. Correspondence Douglas L Black. Email dougb@ Published 26 May 2006 Genome Biology 2006 7 317 doi gb-2006-7-5-3l7 The electronic version of this article is the complete one and can be found online at http 2006 7 5 317 2006 BioMed Central Ltd A report on the 2nd Symposium on Alternative Transcript Diversity Heidelberg Germany 21-23 March 2006. Alternative splicing affects many aspects of eukaryotic biology and is studied by groups with diverse interests. Geneticists and biochemists have long been interested in understanding the molecular mechanisms that underlie changes in splice-site choice and the role of splicing regulation in particular biological systems. More recently computational biologists have entered the field with the goals of defining the products of genomes and understanding the role of alternative splicing in genome evolution. Although their interests broadly overlap these fields often utilize distinct languages and there have been relatively few meetings dedicated to bringing the two groups together. Exceptions have been the symposia on alternative transcript diversity organized by the European Molecular Biology Laboratory-European Bioinformatics Institute EMBL-EBI the second symposium was held in March in Heidelberg. This meeting made clear that the interests of these two groups coincide more than ever and that combining genomic approaches with mechanistic analyses is leading to significant new understanding of splicing regulation. The combined approach was apparent in the opening talk given by one of us . describing the .
