Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide detection and analysis of homologous recombination among sequenced strains of Escherichia coli. | Research Open Access Genome-wide detection and analysis of homologous recombination among sequenced strains of Escherichia coli Bob Mail Jeremy D Glasner Aaron E Darling and Nicole T Perna 11 Addresses Department of Mathematics Lincoln Drive University of Wisconsin Madison WI 53706 USA. Department of Oncology University Ave University of Wisconsin Madison WI 53706 USA. Genome Center of Wisconsin Henry Mall University of Wisconsin Madison WI 53706 USA. Department of Computer Science W. Dayton St University of Wisconsin Madison WI 53706 USA. Department of Animal Health and Biomedical Sciences Linden Drive University of Wisconsin Madison WI 53706 USA. Correspondence Bob Mau. Email bobmau@ Published 31 May 2006 Genome Biology 2006 7 R44 doi 186 gb-2006-7-5-r44 The electronic version of this article is the complete one and can be found online at http 2006 7 5 R44 Received 1 November 2005 Revised 8 February 2006 Accepted 8 May 2006 2006 Mau et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Comparisons of complete bacterial genomes reveal evidence of lateral transfer of DNA across otherwise clonally diverging lineages. Some lateral transfer events result in acquisition of novel genomic segments and are easily detected through genome comparison. Other more subtle lateral transfers involve homologous recombination events that result in substitution of alleles within conserved genomic regions. This type of event is observed infrequently among distantly related organisms. It is reported to be more common within species but the frequency has been difficult to quantify since the sequences under comparison tend to have relatively few polymorphic sites. Results Here we report
