Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: A steganalysis-based approach to comprehensive identification and characterization of functional regulatory elements. | Method Open Access A steganalysis-based approach to comprehensive identification and characterization of functional regulatory elements Guandong Wang and Weixiong Zhang Addresses Department of Computer Science and Engineering Washington University St. Louis MO 63130 USA. ỶDepartment of Genetics Washington University St. Louis MO 63130 USA. Correspondence Weixiong Zhang. Email zhang@ Published 20 June 2006 Genome Biology 2006 7 R49 doi 186 gb-2006-7-6-r49 The electronic version of this article is the complete one and can be found online at http 2006 7 6 R49 Received 3 February 2006 Revised 10 April 2006 Accepted l7 May 2006 2006 Wang and Zhang licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The comprehensive identification of c s-regulatory elements on a genome scale is a challenging problem. We develop a novel steganalysis-based approach for genome-wide motif finding called WordSpy by viewing regulatory regions as a stegoscript with c s-elements embedded in background sequences. We apply WordSpy to the promoters of cell-cycle-related genes of Saccharomyces cerev s ae and Arab dops s thal ana identifying all known cell-cycle motifs with high ranking. WordSpy can discover a complete set of c s-elements and facilitate the systematic study of regulatory networks. Background The comprehensive identification and characterization of short functional sequence elements has become increasingly important as we begin to elucidate transcriptional regulation on a large scale. Transcriptional regulation involves a complex molecular network. The interaction of transcription factors TFs and cfs-acting DNA elements determines the expression levels of different genes under various environmental .
