Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Identification, characterization and comparative genomics of chimpanzee endogenous retroviruses. | Open Access Research Identification characterization and comparative genomics of chimpanzee endogenous retroviruses Nalini Polavarapu Nathan J Bowen and John F McDonald Address School of Biology Georgia Institute of Technology Atlanta Georgia 30332-0230 USA. Correspondence John F McDonald. Email Published 28 June 2006 Genome Biology 2006 7 R51 doi l86 gb-2006-7-6-r5l The electronic version of this article is the complete one and can be found online at http 2006 7 6 R51 Received 29 March 2006 Revised 23 May 2006 Accepted 25 May 2006 2006 Polavarapu et al. BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Retrotransposons the most abundant and widespread class of eukaryotic transposable elements are believed to play a significant role in mutation and disease and to have contributed significantly to the evolution of genome structure and function. The recent sequencing of the chimpanzee genome is providing an unprecedented opportunity to study the functional significance of these elements in two closely related primate species and to better evaluate their role in primate evolution. Results We report here that the chimpanzee genome contains at least 42 separate families of endogenous retroviruses nine of which were not previously identified. All but two CERV 1 PTERV1 and CERV 2 of the 42 families of chimpanzee endogenous retroviruses were found to have orthologs in humans. Molecular analysis PCR and Southern hybridization of CERV 2 elements demonstrates that this family is present in chimpanzee bonobo gorilla and old-world monkeys but absent in human orangutan and new-world monkeys. A survey of endogenous retroviral positional variation between chimpanzees and .
