Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: What makes species unique? The contribution of proteins with obscure features. | Open Access Research What makes species unique The contribution of proteins with obscure features Martin Gollery Jeff Harper John Cushman Taliah Mittler Thomas Girke Jian-Kang Zhu Julia Bailey-Serres and Ron Mittler Addresses Department of Biochemistry and Molecular Biology University Of Nevada Reno NV 89557 USA. Center for Plant Cell Biology University Of California Riverside CA 92521 USA. Correspondence Ron Mittler. Email ronm@ Published 19 July 2006 Received 06 March 2006 Revised 28 April 2006 Genome Biology 2006 7 R57 doi 186 gb-2006-7-7-r57 gy g Accepted 27 June 2006 The electronic version of this article is the complete one and can be found online at http 2006 7 7 R57 2006 Gollery et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Proteins with obscure features POFs which lack currently defined motifs or domains represent between 18 and 38 of a typical eukaryotic proteome. To evaluate the contribution of this class of proteins to the diversity of eukaryotes we performed a comparative analysis of the predicted proteomes derived from 10 different sequenced genomes including budding and fission yeast worm fly mosquito Arabidopsis rice mouse rat and human. Results Only 1 650 protein groups were found to be conserved among these proteomes BLAST E-value threshold of 10-6 . Of these only three were designated as POFs. Surprisingly we found that on average 60 of the POFs identified in these 10 proteomes 44 236 in total were species specific. In contrast only of the proteins with defined features PDFs were species specific 17 554 in total . As a group POFs appear similar to PDFs in their relative contribution to biological functions as indicated by their expression .
