Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Co-evolution of transcription factors and their targets depends on mode of regulation. | Open Access Co-evolution of transcription factors and their targets depends on mode of regulation Ruth Hershberg and Hanah Margalit Address Department of Molecular Genetics and Biotechnology Faculty of Medicine The Hebrew University of Jerusalem Jerusalem 91120 Israel. Correspondence Hanah Margalit. Email hanah@ Published 19 July 2006 Genome Biology 2006 7 R62 doi 186 gb-2006-7-7-r62 The electronic version of this article is the complete one and can be found online at http 2006 7 7 R62 Received 7 March 2006 Revised 30 May 2006 Accepted 13 July 2006 2006 Hershberg and Margalit licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Differences in the transcription regulation network are at the root of much of the phenotypic variation observed among organisms. These differences may be achieved either by changing the repertoire of regulators and or their targets or by rewiring the network. Following these changes and studying their logic is crucial for understanding the evolution of regulatory networks. Results We use the well characterized transcription regulatory network of Escherichia coli K12 and follow the evolutionary changes in the repertoire of regulators and their targets across a large number of fully sequenced Y-proteobacteria. By focusing on close relatives of E. coli K12 we study the dynamics of the evolution of transcription regulation across a relatively short evolutionary timescale. We show significant differences in the evolution of repressors and activators. Repressors are only lost from a genome once their targets have themselves been lost or once the network has significantly rewired. In contrast activators are often lost even when their targets remain in the
