Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Advances in the genetics and epigenetics of gene regulation and human disease. | Meeting report Advances in the genetics and epigenetics of gene regulation and human disease Kristine Kleivi Addresses Medical Biotechnology VTT Technical Research Center of Finland 20521 Turku Finland and Department of Genetics Institute for Cancer Research Rikshospitalet-Radiumhospitalet Medical Center 0310 Oslo Norway. Email Published 24 August 2006 Genome Biology 2006 7 325 doi gb-2006-7-8-325 The electronic version of this article is the complete one and can be found online at http 2006 7 8 325 2006 BioMed Central Ltd A report on the Human Genome Organisation HUGO 11th Human Genome Meeting Helsinki Finland 31 May-3 June 2006. At the recent annual meeting on the human genome in Helsinki organized by the Human Genome Organisation HUGO close to 700 scientists gathered to present and discuss the latest advances in genome research. This report presents some selected highlights. Genome variation gene expression and disease susceptibility Through their effects on gene expression polymorphisms in the human genome can contribute to phenotypic variation and disease susceptibility. For many diseases such as cancer great effort is being made to study the sequence variants that contribute to disease susceptibility. The impact of genetic variation on common diseases was addressed by Kari Stefansson deCODE Genetics Reykjavik Iceland who gave an update on the identified sequence variants that may increase the risk of developing type 2 diabetes prostate cancer myocardial infarction stroke and schizophrenia. In the past decades type 2 diabetes has become a major health problem in the Western world as both its incidence and its prevalence have increased rapidly. Stefansson reported his group s recent discovery of an inherited variant of the gene TCF7L7 encoding a protein called transcription factor 7-like 2 located on chromosome 10 which is estimated to account for about 20 of the diabetes cases. They have also showed an .
